GammaKnife™ radiosurgery for Fisch-classified jugulotympanic paragangliomas: Review of the measures and timing of treatment success
Federico Ampil, Anthony Sin, Donald Smith and Troy Richards
Jugulotympanic paraganglioma (JTPG), a benign slow-growing neoplasm in the skull base with a tendency to be locally invasive, poses a treatment challenge because of its proximity to nearby neurovascular structures. The authors describe 11 patents with 12 Fisch-classified JTPGs treated with GammaKnife radiosurgery (GKRS) during a 12-year period. The observed rates of subjective improvement and tumor control were 80% and 83%, respectively. Among the individuals living longer than 5 years, tumor growth developed at 77 and 180 months after radiosurgery in two patients. Treatment-related toxicity or radiation oncogenesis was not observed. GKRS seems to be a valid treatment option for all Fisch designated skull base glomus tumors. Life-long follow-up of these patients is necessary.
Keywords: Paraganglioma, glomus tympanicum, glomus jugulare, GammaKnife radiosurgery, skull base neoplasm
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