- Journal Contents Downloads
- JRSBRT Downloads
- JRSBRT 8.3, p. 181-187
Lung stereotactic body radiation therapy using simultaneous integrated BED-escalation for peripherally located non-small cell lung cancer
Colton J. Ladbury and Sagus Sampath
Purpose: Report the outcomes of patients with non-small cell lung cancer (NSCLC) and peripheral tumors treated with simultaneous integrated biologically equivalent dose (BED)-escalation (SIBE) lung stereotactic body radiation therapy (SBRT) to achieve dose escalation.
Materials/methods: Patients with NSCLC within 5 mm of the chest wall treated with a SIBE approach were eligible. Patients received 60 Gy in 5 fractions, with dose decreased to 50 Gy based on proximity to the chest wall. Dosimetry, oncologic outcomes, and toxicity were evaluated.
Results: Twenty-four patients met inclusion criteria. Median BED to the PTV was 135.4 Gy. Median chest wall V30 was 18.7 cc. The 3-year LC, OS, and PFS of the non-metastatic cohort was 93%, 35%, and 39%, respectively. The crude rate of chest wall toxicity was 12.5%, with no rib fractures.
Conclusions: SIBE lung SBRT appears to be well tolerated and achieves favorable local control rates and survival.
Keywords: lung SBRT, chest wall toxicity, SIB, NSCLC, dose escalation
After payment has been processed for your order of a digital copy (PDF) of this article, you will see a download link on your completed order page and also receive an email containing a download link. The links, which will enable you to download one copy of the article, will expire after 24 hours.