Effect of stereotactic body radiotherapy beyond primary target in prostate cancer
Jay P. Sahu, Trinanjan Basu, Shounak J. Kamat, Ajinkya Gadekar, Rohith R. Menon and Ghazala K. Roshan
A phenomenon where an untreated metastatic site shows response concurrently while another site is undergoing a localized treatment is known as abscopal effect. Although the exact mechanism is not completely known it is postulated that the immune system is responsible for such an effect [1].
Stereotactic body radiation therapy (SBRT) is a high-precision radiation treatment that delivers large, daily doses of radiation in a small number of fractions. Several studies have demonstrated the safety and efficacy of SBRT for treatment of prostate cancer [2-5]. Moreover, SBRT is now regarded as a radiation regimen for all-risk category of clinically localized prostate cancers [6].
This report details the effect of radiotherapy beyond the primary target in a case of prostate cancer treated by SBRT by using prostate-specific membrane antigen–positron emission tomography–computed tomography (PSMA PET CT) for response evaluation.
Keywords: prostate cancer, SBRT, abscopal effect, PSMA PET CT, PSA
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