- Journal Contents Downloads
- JRSBRT Downloads
- JRSBRT 2.3, p. 225-233
Lung stereotactic body radiotherapy using a coplanar versus a non-coplanar beam technique: a comparison of clinical outcomes
Christopher L. Hallemeier, Michael C. Stauder, Robert C. Miller, Yolanda I. Garces, Robert L. Foote, Jann N. Sarkaria, Heather J. Bauer, Charles S. Mayo, and Kenneth R. Olivier
Objectives: To determine if lung stereotactic body radiotherapy (SBRT) using a coplanar beam technique was associated with similar outcomes as lung SBRT using a non-coplanar beam technique.
Methods: A retrospective review was performed of patients undergoing lung SBRT between January 2008 and April 2011. SBRT was initially delivered with multiple non-coplanar, non-overlapping beams; however, starting in December 2009, SBRT was delivered predominantly with all coplanar beams in order to reduce treatment time and complexity.
Results: This analysis included 149 patients; the median follow-up was 21 months. SBRT was delivered for primary (n = 90) or recurrent (n = 17) non-small cell lung cancer, or lung oligometastasis (n = 42). The most common dose (Gy)/fraction (fx) regimens were 48 Gy/4 fx (39%), 54 Gy/3 fx (37%), and 50 Gy/5 fx (17%). The beam arrangement was coplanar in 61 patients (41%) and non-coplanar in 88 patients (59%). In patients treated with 54 Gy/3 fx, the mean treatment times per fraction for the coplanar and non-coplanar cohorts were 10 and 14 minutes (p < 0.0001). Kaplan-Meier 2-year estimates of overall survival (OS), progression free survival, and local control (LC) for the coplanar and non-coplanar cohorts were 65% vs. 56% (p = 0.30), 47% vs. 39% (p = 0.71), and 92% and 92% (p = 0.94), respectively. The 1-year estimates of grade 2-5 pulmonary toxicity for the coplanar and non-coplanar cohorts were 11% and 17%, respectively (p = 0.30). On multivariate analysis, beam arrangement was not significantly associated with OS, LC or pulmonary toxicity.
Conclusions: Patients treated with lung SBRT using a coplanar technique had similar outcomes as those treated with a non-coplanar technique.
Keywords: stereotactic body radiotherapy, non-small cell lung cancer, lung metastases, radiation pneumonitis, local control, 4DCT
After payment has been processed for your order of a digital copy (PDF) of this article, you will see a download link on your completed order page and also receive an email containing a download link. The links, which will enable you to download one copy of the article, will expire after 24 hours.